Platelet signal transduction, metabolism and programmed cell death

Despite being the smallest cells of human organism, platelets have incredibly complex intracellular machinery. Their cytoplasm contains dense tubular system, mitochondria, various granules, glycogen, actin-myosin system, and powerful cytoskeleton capable of lightning-quick rearrangement. Dozens of receptors on their surface detect various chemical and physical signals and transduce them into the cell. Then an immensely huge network of signal transduction decideswhether and how to get activated, or probably to go into one of the programmed cell death routes. We try to understand how all this works.

Systems biology insights into the meaning of the platelet’s dual-receptor thrombin signaling

Anastasia N. Sveshnikova, Alexander V. Balatskiy, Aleksandra S. Demianova, Taisiya O. Shepelyuk, Soslan S. Shakhidzhanov, Maria N. Balatskaya, Alexey V. Pichugin, Fazoil I. Ataullakhanov, and Mikhail A. Panteleev.

 Journal of Thrombosis and Haemostasis, 2016

Dynamics of calcium spiking, mitochondrial collapse and phosphatidylserine exposure in platelet subpopulations during activation

SI Obydennyy, AN Sveshnikova, FI Ataullakhanov, and MA Panteleev. 

Journal of Thrombosis and Haemostasis, 2016

Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase c and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations.

Fedor A. Balabin and Anastasia N. Sveshnikova.

 Mathematical Biosciences, 276:67–74, 2016

Modulation and pre-amplification of PAR1 signaling by ADP acting via the P2Y12 receptor during platelet subpopulation formation.

Shakhidzhanov SS, Shaturny VI, Panteleev MA, Sveshnikova AN.

Biochim Biophys Acta. 2015 Dec;1850(12):2518-29. doi: 10.1016/j.bbagen.2015.09.013

Calpain-controlled detachment of major glycoproteins from cytoskeleton regulates adhesive properties of phosphatidylserine-positive activated platelets.

Artemenko EO, Yakimenko AO, Pichugin AV, Ataullakhanov FI, Panteleev MA.

Biochem J. 2015 Nov 25. pii: BJ20150779.

Compartmentalized calcium signaling triggers subpopulation formation upon platelet activation through PAR1.

Sveshnikova AN, Ataullakhanov FI, Panteleev MA.

Mol Biosyst. 2015 Apr;11(4):1052-60. doi: 10.1039/c4mb00667d

[Activators, receptors and signal transduction pathways of blood platelets].

Shaturnyĭ VI, Shakhidzhanov SS, Sveshnikova AN, Panteleev MA.

Biomed Khim. 2014 Mar-Apr;60(2):182-200. Review. Russian

Identification of signal transduction pathways involved in the formation of plateletsubpopulations upon activation.

Topalov NN, Kotova YN, Vasil'ev SA, Panteleev MA.

Br J Haematol. 2012 Apr;157(1):105-15. doi: 10.1111/j.1365-2141.2011.09021.x. Epub 2012 Jan 16.

Formation of coated platelets is regulated by the dense granule secretion of adenosine 5'diphosphate acting via the P2Y12 receptor.

Kotova YN, Ataullakhanov FI, Panteleev MA.

J Thromb Haemost. 2008 Sep;6(9):1603-5. doi: 10.1111/j.1538-7836.2008.03052.x. Epub 2008 Jun 6. No abstract available.