Clinical and translational research

Although we love the beauty of basic research, it is always great to do something useful for the humanity. Our main lines of applied research include:

- Investigating molecular mechanisms of bleeding and thrombotic disorders

- Development and application of innovative approaches and devices in hemostasis diagnostics

- Development of new anti-thrombotic and pro-hemostatic drug candidates

- Investigation of the existing therapeutic approaches

- Research of blood components: methods of production, storage and application

Functional characteristics and clinical effectiveness of platelet concentrates treated with riboflavin and ultraviolet light in plasma and in platelet additive solution.

Ignatova AA, Karpova OV, Trakhtman PE, Rumiantsev SA, Panteleev MA.

Vox Sang. 2015 Dec 8. doi: 10.1111/vox.12364.

New Infestin-4 Mutants with Increased Selectivity against Factor XIIa.

Kolyadko VN, Lushchekina SV, Vuimo TA, Surov SS, Ovsepyan RA, Korneeva VA, Vorobiev II, Orlova NA, Minakhin L, Kuznedelov K, Severinov KV, Ataullakhanov FI, Panteleev MA.

PLoS One. 2015 Dec 15;10(12):e0144940. doi: 10.1371/journal.pone.0144940. eCollection 2015.

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects.

Panteleev MA, Hemker HC.

Thromb J. 2015 Jan 28;13(1):5. doi: 10.1186/s12959-014-0032-y. eCollection 2015.

Procoagulant impact of the plasmapheresis procedure on coagulation state of collected plasma.

Surov S, Ovsepyan R, Vysochin I, Kobzeva E, Khvatov V, Panteleev M, Vuimo T.

Blood Transfus. 2015 Oct;13(4):651-5. doi: 10.2450/2015.0315-14. Epub 2015 Jul 9. No abstract available.

Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor VIII: studies of spatial dynamics of fibrin clot formation in hemophilia A.

Parunov LA, Soshitova NP, Fadeeva OA, Balandina AN, Kopylov KG, Kumskova MA, Gilbert JC, Schaub RG, McGinness KE, Ataullakhanov FI, Panteleev MA.

Thromb Res. 2014 Jan;133(1):112-9. doi: 10.1016/j.thromres.2013.10.036. Epub 2013 Nov 1.

Interactions outside the proteinase-binding loop contribute significantly to the inhibition of activated coagulation factor XII by its canonical inhibitor from corn.

Korneeva VA, Trubetskov MM, Korshunova AV, Lushchekina SV, Kolyadko VN, Sergienko OV, Lunin VG, Panteleev MA, Ataullakhanov FI.

J Biol Chem. 2014 May 16;289(20):14109-20. doi: 10.1074/jbc.M114.553735.

Investigation of the phenotype heterogeneity in severe hemophilia A using thromboelastography, thrombin generation, and thrombodynamics.

Tarandovskiy ID, Balandina AN, Kopylov KG, Konyashina NI, Kumskova MA, Panteleev MA, Ataullakhanov FI.

Thromb Res. 2013 Jun;131(6):e274-80. doi: 10.1016/j.thromres.2013.04.004. Epub 2013 Apr 20

Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications.

Tarandovskiy ID, Artemenko EO, Panteleev MA, Sinauridze EI, Ataullakhanov FI.

PLoS One. 2013;8(2):e55688. doi: 10.1371/journal.pone.0055688. Epub 2013 Feb 6.

Predicting prothrombotic tendencies in sepsis using spatial clot growth dynamics.

Soshitova NP, Karamzin SS, Balandina AN, Fadeeva OA, Kretchetova AV, Galstian GM,Panteleev MA, Ataullakhanov FI.

Blood Coagul Fibrinolysis. 2012 Sep;23(6):498-507. doi: 10.1097/MBC.0b013e328352e90e.

Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation.

Parunov LA, Fadeeva OA, Balandina AN, Soshitova NP, Kopylov KG, Kumskova MA, Gilbert JC, Schaub RG, McGinness KE, Ataullakhanov FI, Panteleev MA.

J Thromb Haemost. 2011 Sep;9(9):1825-34. doi: 10.1111/j.1538-7836.2011.04412.x.

Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution.

Ovanesov MV, Panteleev MA, Sinauridze EI, Kireev DA, Plyushch OP, Kopylov KG, Lopatina EG, Saenko EL, Ataullakhanov FI.

Blood Coagul Fibrinolysis. 2008 Dec;19(8):743-55. doi: 10.1097/MBC.0b013e3283104093