Platelet adhesion and aggregation

Platelets have many important roles, but the most direct and prominent one is to prevent bleeding by forming aggregates. When something goes wrong, they form life-threatening thrombi. The processes of platelet adhesion and aggregation are very hard to understand because they combine all possible types of complexity: hydrodynamical, mechanical, chemical ones... A combination of supercomputer-based models and hi-end confocal/TIRF/electron microscopy methods (sometimes using perfusion flow chambers, sometimes intravital approaches with genetically modified mice and various bleeding models) allows us to get insight into the mechanisms of thrombus formation, regulation of thrombus size and stability, difference between thrombosis and hemostasis.

Threshold of microvascular occlusion: injury size defines the thrombosis scenario.

Belyaev AV, Panteleev MA, Ataullakhanov FI.

Biophys J. 2015 Jul 21;109(2):450-6. doi: 10.1016/j.bpj.2015.06.019

Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation.

Babushkina ES, Bessonov NM, Ataullakhanov FI, Panteleev MA.

PLoS One. 2015 Oct 30;10(10):e0141068. doi: 10.1371/journal.pone.0141068. eCollection 2015

Modelling of thrombus growth in flow with a DPD-PDE method.

Tosenberger A, Ataullakhanov F, Bessonov N, Panteleev M, Tokarev A, Volpert V.

J Theor Biol. 2013 Nov 21;337:30-41. doi: 10.1016/j.jtbi.2013.07.023. Epub 2013 Jul 31.

Identification of different proaggregatory abilities of activated platelet subpopulations.

Yakimenko AO, Verholomova FY, Kotova YN, Ataullakhanov FI, Panteleev MA.

Biophys J. 2012 May 16;102(10):2261-9. doi: 10.1016/j.bpj.2012.04.004. Epub 2012 May 15