Platelets have many important roles, but the most direct and prominent one is to prevent bleeding by forming aggregates. When something goes wrong, they form life-threatening thrombi. The processes of platelet adhesion and aggregation are very hard to understand because they combine all possible types of complexity: hydrodynamical, mechanical, chemical ones... A combination of supercomputer-based models and hi-end confocal/TIRF/electron microscopy methods (sometimes using perfusion flow chambers, sometimes intravital approaches with genetically modified mice and various bleeding models) allows us to get insight into the mechanisms of thrombus formation, regulation of thrombus size and stability, difference between thrombosis and hemostasis.
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